A Wyndham man is among 63 people drink driving on the Princes Freeway.
Police stopped almost 350 vehicles in the Altona area over the weekend, finding dozens of drink drivers.
Five also allegedly tested positive to drugs.
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A Point Cook man allegedly blew 0.164 after he was stopped at the booze bus, more than three times the blood alcohol limit.
The 32-year-old lost his licence for 12 months, his car impounded and he will also be facing charges.
Police are warning drivers they will not tolerate drink and drug driving, saying there are significant penalties for those who blatantly disregard the rules.